Huge Pelvi-Abdominal Malignant Inflammatory Myofibroblastic Tumor

Inflammatory myofibroblastic tumor (IMT) is an uncommon benign neoplasm with locally aggressive behavior but malignant change is rare. Such a rare tumor occurring in a 14-year-old patient with clinical presentations of abdominal pain and body weight loss was seldom described before.



A research article published in the World Journal of Gastroenterology addresses this problem. A research team led by Professor Ko from Chang Gung University College of Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Taiwan, reported that computed tomography was useful for clear delineation of this huge pelvic-abdominal mass with extraperitoneal origin and prominent peritumoral vascularity which was crucial for surgical planning. Subsequent surgery, histopathology, immunohistochemistry, DNA sequencing and electron microscopy confirmed the final diagnosis of inflammatory myofibroblastic tumor with malignant transformation. Despite radical tumor resection, rapid tumor recurrence occurred in the lower abdomen 20 days after discharge.



This report documents the first known case of pelvic extraperitoneal IMT with malignant transformation in a pediatric patient. In light of this case, IMT should be considered in the differential diagnosis of pelvi-abdominal mass with large central necrosis and the presence of prominent peritumoral vascularity may also be a clue of high metabolic demand and even malignant transformation.



Reference:
Lu CH, Huang HY, Chen HK, Chuang JH, Ng SH, Ko SF. Huge pelvi-abdominal malignant inflammatory myofibroblastic tumor with rapid recurrence in a 14-year-old boy. World J Gastroenterol 2010; 16(21): 2698-2701

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